diff --git a/biology/htslib/Makefile b/biology/htslib/Makefile
index d4512851afd1..91b667286d6f 100644
--- a/biology/htslib/Makefile
+++ b/biology/htslib/Makefile
@@ -1,7 +1,7 @@
 # Created by: Reed A. Cartwright <cartwright@asu.edu>
 
 PORTNAME=	htslib
-DISTVERSION=	1.14
+DISTVERSION=	1.15
 CATEGORIES=	biology devel
 # Github generated distfiles are incomplete, so use custom tarball
 MASTER_SITES=	https://github.com/samtools/htslib/releases/download/${DISTVERSION}/
diff --git a/biology/htslib/distinfo b/biology/htslib/distinfo
index aefd3caacc9e..49defada0080 100644
--- a/biology/htslib/distinfo
+++ b/biology/htslib/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1639702310
-SHA256 (htslib-1.14.tar.bz2) = ed221b8f52f4812f810eebe0cc56cd8355a5c9d21c62d142ac05ad0da147935f
-SIZE (htslib-1.14.tar.bz2) = 4136564
+TIMESTAMP = 1645831536
+SHA256 (htslib-1.15.tar.bz2) = 1a9f49911503a22f56817cc82ea9b87fb7e7467b5ff989ca5aa61c12e7d532d9
+SIZE (htslib-1.15.tar.bz2) = 4141168