diff --git a/math/py-rpy2/Makefile b/math/py-rpy2/Makefile
index c3372506de16..f7af1f988949 100644
--- a/math/py-rpy2/Makefile
+++ b/math/py-rpy2/Makefile
@@ -1,5 +1,5 @@
 PORTNAME=	rpy2
-PORTVERSION=	3.5.15
+PORTVERSION=	3.5.16
 CATEGORIES=	math python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
@@ -18,7 +18,7 @@ BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cffi>=1.15.0:devel/py-cffi@${PY_FLAVOR} \
 LIB_DEPENDS=	libR.so:math/R \
 		libicui18n.so:devel/icu \
 		libpcre2-8.so:devel/pcre2
-RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cffi>=1.15.0:devel/py-cffi@${PY_FLAVOR} \
+RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cffi>=1.15.1:devel/py-cffi@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}Jinja2>=0:devel/py-Jinja2@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tzlocal>=0:devel/py-tzlocal@${PY_FLAVOR}
 
diff --git a/math/py-rpy2/distinfo b/math/py-rpy2/distinfo
index a5b92f74d0bb..07b3148a7d36 100644
--- a/math/py-rpy2/distinfo
+++ b/math/py-rpy2/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1708449406
-SHA256 (rpy2-3.5.15.tar.gz) = 444fae4a84dc7f233b70eaab0aa81398ee0147c4e1ae38dd4524d779d6f25b2b
-SIZE (rpy2-3.5.15.tar.gz) = 219822
+TIMESTAMP = 1712084528
+SHA256 (rpy2-3.5.16.tar.gz) = 837e2f74583658a5c4c339761a73f9434f33ef9ced3e30c64da7562165c2801b
+SIZE (rpy2-3.5.16.tar.gz) = 220028