diff --git a/science/Makefile b/science/Makefile
index 7c4802f84815..8a9535da9c1f 100644
--- a/science/Makefile
+++ b/science/Makefile
@@ -498,6 +498,7 @@
     SUBDIR += spglib
     SUBDIR += spheral
     SUBDIR += step
+    SUBDIR += sz3
     SUBDIR += tblite
     SUBDIR += teem
     SUBDIR += tfel
diff --git a/science/sz3/Makefile b/science/sz3/Makefile
new file mode 100644
index 000000000000..e65b8ad06873
--- /dev/null
+++ b/science/sz3/Makefile
@@ -0,0 +1,39 @@
+PORTNAME=	sz3
+PORTVERSION=	3.2.1
+DISTVERSIONPREFIX=	v
+CATEGORIES=	science
+
+MAINTAINER=	sunpoet@FreeBSD.org
+COMMENT=	Modular Error-bounded Lossy Compression Framework for Scientific Datasets
+WWW=		https://szcompressor.org/ \
+		https://github.com/szcompressor/SZ3
+
+LICENSE=	BSD4CLAUSE
+LICENSE_FILE=	${WRKSRC}/copyright-and-BSD-license.txt
+
+LIB_DEPENDS=	libgsl.so:math/gsl \
+		libzstd.so:archivers/zstd
+
+USES=		cmake pkgconfig
+
+CMAKE_OFF=	BUILD_H5Z_FILTER \
+		BUILD_MDZ \
+		SZ3_DEBUG_TIMINGS \
+		SZ3_USE_BUNDLED_ZSTD
+CMAKE_ON=	BUILD_SHARED_LIBS \
+		BUILD_STATIC_LIBS
+
+DATADIR=	${PREFIX}/share/SZ3
+
+USE_GITHUB=	yes
+GH_ACCOUNT=	szcompressor
+GH_PROJECT=	SZ3
+
+post-patch:
+# Clean up bundled libraries
+	@${RM} -r ${WRKSRC}/tools/zstd/
+
+post-install:
+	${STRIP_CMD} ${STAGEDIR}${PREFIX}/bin/sz3*
+
+.include <bsd.port.mk>
diff --git a/science/sz3/distinfo b/science/sz3/distinfo
new file mode 100644
index 000000000000..638b3b67e6a1
--- /dev/null
+++ b/science/sz3/distinfo
@@ -0,0 +1,3 @@
+TIMESTAMP = 1738088812
+SHA256 (szcompressor-SZ3-v3.2.1_GH0.tar.gz) = 24ed1c8159832734a241df66b857eca64d18a2e8e949ef583a2d0bfe01c6b7e1
+SIZE (szcompressor-SZ3-v3.2.1_GH0.tar.gz) = 4474033
diff --git a/science/sz3/pkg-descr b/science/sz3/pkg-descr
new file mode 100644
index 000000000000..8cba5dafde49
--- /dev/null
+++ b/science/sz3/pkg-descr
@@ -0,0 +1,16 @@
+SZ is a modular parametrizable lossy compressor framework for scientific data
+(floating point and integers). It has applications in simulations, AI and
+instruments. It is a production quality software and a research platform for
+lossy compression. SZ is open and transparent. Open because all interested
+researchers and students can study or contribute to it. Transparent because all
+performance improvements are detailed in publications.
+
+SZ can be used for classic use-cases: visualization, accelerating I/O, reducing
+memory and storage footprint and more advanced use-cases like compression of DNN
+models and training sets, acceleration of computation, checkpoint/restart,
+reducing streaming intensity and running efficiently large problems that cannot
+fit in memory. Other use-cases will augment this list as users find new
+opportunities to benefit from lossy compression of scientific data.
+
+SZ has implementations on CPU, GPU, and FPGA and is integrated in the main I/O
+libraries: HFD5, ADIOS, PnetCDF.
diff --git a/science/sz3/pkg-plist b/science/sz3/pkg-plist
new file mode 100644
index 000000000000..cbe94507605e
--- /dev/null
+++ b/science/sz3/pkg-plist
@@ -0,0 +1,70 @@
+bin/sz3
+bin/sz3_smoke_test
+include/SZ3/api/impl/SZAlgoInterp.hpp
+include/SZ3/api/impl/SZAlgoLorenzoReg.hpp
+include/SZ3/api/impl/SZAlgoNopred.hpp
+include/SZ3/api/impl/SZDispatcher.hpp
+include/SZ3/api/impl/SZImpl.hpp
+include/SZ3/api/impl/SZImplOMP.hpp
+include/SZ3/api/sz.hpp
+include/SZ3/compressor/Compressor.hpp
+include/SZ3/compressor/SZGenericCompressor.hpp
+include/SZ3/compressor/SZIterateCompressor.hpp
+include/SZ3/compressor/specialized/SZBlockInterpolationCompressor.hpp
+include/SZ3/compressor/specialized/SZExaaltCompressor.hpp
+include/SZ3/compressor/specialized/SZTruncateCompressor.hpp
+include/SZ3/decomposition/Decomposition.hpp
+include/SZ3/decomposition/InterpolationDecomposition.hpp
+include/SZ3/decomposition/LorenzoRegressionDecomposition.hpp
+include/SZ3/decomposition/NoPredictionDecomposition.hpp
+include/SZ3/decomposition/TimeSeriesDecomposition.hpp
+include/SZ3/def.hpp
+include/SZ3/encoder/ArithmeticEncoder.hpp
+include/SZ3/encoder/BypassEncoder.hpp
+include/SZ3/encoder/Encoder.hpp
+include/SZ3/encoder/HuffmanEncoder.hpp
+include/SZ3/encoder/RunlengthEncoder.hpp
+include/SZ3/lossless/Lossless.hpp
+include/SZ3/lossless/Lossless_bypass.hpp
+include/SZ3/lossless/Lossless_zstd.hpp
+include/SZ3/predictor/ComposedPredictor.hpp
+include/SZ3/predictor/LorenzoPredictor.hpp
+include/SZ3/predictor/MetaLorenzoPredictor.hpp
+include/SZ3/predictor/MetaRegressionPredictor.hpp
+include/SZ3/predictor/PolyRegressionCoeffAux.hpp
+include/SZ3/predictor/PolyRegressionCoeffAux.m
+include/SZ3/predictor/PolyRegressionPredictor.hpp
+include/SZ3/predictor/Predictor.hpp
+include/SZ3/predictor/RegressionPredictor.hpp
+include/SZ3/preprocessor/PreFilter.hpp
+include/SZ3/preprocessor/PreProcessor.hpp
+include/SZ3/preprocessor/Transpose.hpp
+include/SZ3/preprocessor/Wavelet.hpp
+include/SZ3/quantizer/LinearQuantizer.hpp
+include/SZ3/quantizer/Quantizer.hpp
+include/SZ3/utils/ByteUtil.hpp
+include/SZ3/utils/Config.hpp
+include/SZ3/utils/Extraction.hpp
+include/SZ3/utils/FileUtil.hpp
+include/SZ3/utils/Interpolators.hpp
+include/SZ3/utils/Iterator.hpp
+include/SZ3/utils/KmeansUtil.hpp
+include/SZ3/utils/MemoryUtil.hpp
+include/SZ3/utils/MetaDef.hpp
+include/SZ3/utils/QuantOptimizatioin.hpp
+include/SZ3/utils/Statistic.hpp
+include/SZ3/utils/Timer.hpp
+include/SZ3/utils/inih/INIReader.h
+include/SZ3/utils/inih/LICENSE.txt
+include/SZ3/utils/ska_hash/LICENSE.txt
+include/SZ3/utils/ska_hash/bytell_hash_map.hpp
+include/SZ3/utils/ska_hash/flat_hash_map.hpp
+include/SZ3/utils/ska_hash/unordered_map.hpp
+include/SZ3/version.hpp
+include/SZ3/version.hpp.in
+include/SZ3c/sz3c.h
+lib/cmake/SZ3/SZ3Config.cmake
+lib/cmake/SZ3/SZ3ConfigVersion.cmake
+lib/cmake/SZ3/SZ3Targets.cmake
+lib/libSZ3c.so
+%%DATADIR%%/testfloat_8_8_128.dat