diff --git a/www/py-respx/Makefile b/www/py-respx/Makefile
index 17e4c36845a5..0c1a67e1acb9 100644
--- a/www/py-respx/Makefile
+++ b/www/py-respx/Makefile
@@ -1,5 +1,5 @@
 PORTNAME=	respx
-PORTVERSION=	0.21.1
+PORTVERSION=	0.22.0
 CATEGORIES=	www python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
@@ -14,7 +14,7 @@ LICENSE_FILE=	${WRKSRC}/LICENSE.md
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
-RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}httpx>=0.21.0:www/py-httpx@${PY_FLAVOR}
+RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}httpx>=0.25.0:www/py-httpx@${PY_FLAVOR}
 
 USES=		python
 USE_PYTHON=	autoplist concurrent pep517
diff --git a/www/py-respx/distinfo b/www/py-respx/distinfo
index 2f52302f6caa..a9bc9cce9a50 100644
--- a/www/py-respx/distinfo
+++ b/www/py-respx/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1711860547
-SHA256 (respx-0.21.1.tar.gz) = 0bd7fe21bfaa52106caa1223ce61224cf30786985f17c63c5d71eff0307ee8af
-SIZE (respx-0.21.1.tar.gz) = 28306
+TIMESTAMP = 1735227984
+SHA256 (respx-0.22.0.tar.gz) = 3c8924caa2a50bd71aefc07aa812f2466ff489f1848c96e954a5362d17095d91
+SIZE (respx-0.22.0.tar.gz) = 28439